We aimed to reveal the true status of epidermal growth factor receptor(EGFR) mutations in Chinese patients with non-small
cell lung cancer (NSCLC) after lung resections. EGFR mutations of surgically resected fresh tumor samples from 697 Chinese
NSCLC patients were analyzed by Amplification Refractory Mutation System (ARMS). Correlations between EGFR mutation hotspots and clinical features were also explored.
Int. J. Mol. Sci. 2013, 14, 24549-24559; doi:10.3390/ijms141224549
Brain metastasis (BM) is a leading cause of death in patients with non-small cell lung cancer (NSCLC). EGFR mutations in primary NSCLC lesions have
been associated with sensitivity to EGFR tyrosine kinase inhibitor (TKI). Therefore, it has become important to understand EGFR mutation status in
BM lesions of NSCLC, and its clinical implications. BM samples of 136 NSCLC patients from South China, in which 15 had paired primary lung tumors, were retrospectively analyzed for EGFR mutation by amplification mutation refractory system (ARMS).
Tumor Biol., 07 November 2013. DOI 10.1007/s 13277-013-1323-9
Treatment with epidermal growth factor receptor (EGFR) tyrosine inhibitors (EGFR-TKIs) provides encour-aging outcomes for advanced non-small cell lung cancer(NSCLC) patients with EGFR mutations.Pleural effusion is a common complication of NSCLC. We compared direct DNA sequencing and ADx Amplification Refractory Mutation System (ADx-ARMS) to detect EGFR mutations in malignant pleural effusion samples.
ONCOLOGY REPORTS, DOI:10.3892/or.2013.2709
Accurate determination of anaplastic lymphoma kinase (ALK) rearrangements is critical in identifying ALK-positive patients for targeted therapy in non-small-cell lung cancer (NSCLC).Fluorescence in situ hybridization(FISH) is the current standard method to detect ALK rearrangements but is technically challenging and costly.
Virchows Arch, 8 August 2013. DOI 10.1007/s00428-013-1472-7
To investigate PIK3CA mutation in Chinese patients with lung squamous cell carcinoma (LSCC) and explore their relationship with clinicopathological profiles.
Chin J Cancer Res, 2013;25(4):416-422
To evaluate the diagnostic value of a novel fully automated immunohistochemistry (IHC) assay for detection of anaplastic
lymphoma kinase (ALK) fusion in a large number of ALK-positive lung adenocarcinoma (ADC) patients.
Annals of Oncology, 24: 2589–2593, 2013