To evaluate the suitability of malignant pleural effusion (MPE) and plasma as surrogate samples for epidermal growth factor
receptor (EGFR) mutation detection, and compare three different detection methods.
J Clin Pathol 2013;0:1–5. doi:10.1136/jclinpath-2013-201728
PIK3CA gene mutations have been detected in many malignancies, but the frequency of different mutations and their role in
the carcinogenesis of lung adenocarcinoma are still unclear.
OncoTargets and Therapy, 2013:6 497-502
To determine the prevalence and clinicopathological features of ROS1 fusions in Chinese patients with non-small-cell lung
Annals of Oncology, 24: 1822–1827, 2013
Anaplastic lymphoma receptor tyrosine kinase (ALK) gene rearrangements occur in a subgroup of non-small cell lung
carcinomas(NSCLCs). The identification of these rearrangements is important for guiding treatment decisions. The aim of our
study was to screen ALK gene fusions in NSCLCs and to compare the results detected by targeted resequencing with results
detected by commonly used methods, including fluorescence in situ hybridization(FISH), immunohistochemistry(IHC),and real-time reverse transcription-PCR(RT-PCR).
BioMed Research International, Volume 2013, Article ID 757490, 9 pages
Previous studies have revealed that EGFRmutation and/or EML4–ALK gene fusion rate was higherin the non-smoker Asian
females with pulmonary adeno-carcinoma. The aim of this study is to determine the dis-tribution of known oncogenic driver mutations in thefemale non-smoker Asian patients with pulmonary adeno-carcinoma.
Cell Biochem Biophys. DOI 10.1007/s12013-012-9384-8
Oncogenic driver mutations are responsible for the initiation and maintenance of non-small-cell lung cancer (NSCLC).
Elucidation of driver mutation occurrence in NSCLC has important clinical implications.
Annals of Oncology Advance Access published December 30, 2012